Added: Jerson Maynor - Date: 30.06.2021 00:02 - Views: 29570 - Clicks: 6985
Brain reward systems are thought to be involved in the reinforcing effect of both cocaine and opiates. In vitro receptor autoradiography was used to determine the effect of chronic, continuous cocaine exposure of 2 weeks duration on [3H]naloxone binding in various regions of rat brain. Although cocaine action in the central nervous system is usually associated with altered dopamine function, we observed that opiate receptor density as labeled by [3H]naloxone was altered by chronic cocaine exposure in critical brain reward regions, including the nucleus accumbens, ventral pallidum, and lateral hypothalamus.
Endogenous opioid activity at opiate receptors in these critical regions may be associated with the reinforcement induced by both cocaine and opiates. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search.
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Similar articles Cocaine alters mu but not delta or kappa opioid receptor-stimulated in situ [35S]GTPgammaS binding in rat brain. Schroeder JA, et al.
PMID: Daily modifications of 3H-naloxone binding sites in the rat brain: a quantitative autoradiographic study. Giardino L, et al. Chronobiol Int. Neural mechanisms of the reinforcing action of cocaine. Wise RA. PMID: Review. Distinct opioid circuits determine the palatability and the desirability of rewarding events. Wassum KM, et al. Epub Jul Brain mechanisms of drug reward and euphoria. Wise RA, et al. Psychiatr Med. See all similar articles. Gibula-Tarlowska E, et al. The role of neuronal nitric oxide synthase in cocaine place preference and mu opioid receptor expression in the nucleus accumbens.
Psychopharmacology Berl. The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors. Root DH, et al. Prog Neurobiol. Epub Apr 6. Zhang Y, et al. Epub Nov Epub Apr 4. See all "Cited by" articles.
Publication types Research Support, U. Gov't, P. MeSH terms Animals Actions. Autoradiography Actions. Male Actions. Rats Actions. Rats, Inbred Strains Actions. Substances Receptors, Opioid Actions. Naloxone Actions. Cocaine Actions. Copy Download.Is cocaine an opiate or opioid
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